“Peu, rarement au bon endroit” Michel Pistor
“Мало редко и в нужное место” Мишель Пистор

Clinical mesotherapy


Clinical (medical) mesotherapy

Spheres of application in clinical medicine

Clinical mesotherapy is a conditionally separated part of mesotherapy.

In such meaning it is a usage of mesotherapy in the clinical medicine.

Spheres of application of mesotherapy in the clinical medicine:

Algology, Obstetrics and gynecolog, Anaesthesiology and resuscitation science

Gastroenterolog, Gerontology and geriatrics, Homeopathy, Dermatology and venereology

Immunology and allergology, Infectious diseases, Cardiology, Addictology

Neurology and neurosurgery, Nephrology, Cancerology, Orthopedics, Otolaryngology

Ophthalmology, Pediatrics, Psychiatry and psychotherapy, Pulmonology

Rheumatology, Rehabilitology, Family medicine, Stomatology, Therapeutics

Traumatology, Urology, Physiotherapy, Phthisiology, Surgery, Endocrinology, etc.

Mesotherapy of pathology of locomotor apparatus

Treatment of organic pathology of joints. The example of treatment of calcining tenopathy of shoulder joints.


Mesotherapy of vascular pathology

Mesotherapeutic methods are efficient for all types of derangements of lymph and blood supply. Depending on the types of derangements and stages of disease, mesotherapy can be used as independent or additional method of treatment. The results of it can be compared to the efficiency of surgery methods of treatment (reperfusions), and sometimes excel them.  Moreover, the most important result of mesotherapeutic methods is the absence of surgical traumas and post-surgical rehabilitation, possibility of longtime supporting and rehabilitation therapy in regimen, convenient for both  doctors and  patients – 1 session per 7-10 days, and later – 1 session per 15-30 days. And also mesotherapy has obvious advantage at the threat of amputation of a part of limbs. Collateral blood supply at critical ischemia is formed so fast and efficient that the problem of amputation doesn’t exist.

Non-surgical treatment of varicosity.

The example of usage of mesotherapy in treatment of varix dilatation of lower extremities.
МЕЗОТЕРАПИЯ УКРАИНЫ Курсы, обучение врачей мезотерапии. Безоперационное лечение варикоза.

МЕЗОТЕРАПИЯ УКРАИНЫ Курсы, обучение врачей мезотерапии. Безоперационное лечение варикоза.

Before and after 6 sessions of mesotherapy.

The patient had a course:
- mesotherapy of spine (treatment of osteochondrosis and neurodystrophy, stimulating therapy of lumbar spine);   - vascular mesotherapy;
- antioxidant and metabolic tissue mesotherapy;
- mesolifting of skin of buttocks and lower extremities;
- manual lymphodrainage.

At the treatment vasoactive preparations (phlebotonics, angioprotectors, preparations for improvement of microcirculation), antioxidants, narcotic and psychoactive drugs, anesthetics, anticoagulants, reparative drugs, tissue metabolics were used

Besides improvement of the condition of veins there are other improvements:  increase of hydrolipodystrophy manifestations (cellulite), improvement of general somatic condition, decrease of osteochondrosis manifestations, cutt off of cranialgic syndrome.

Non-surgical treatment of arteriosclerosis obliterans.

The example of usage of mesotherapy in the treatment of critical ischemia of lower extremities.

МЕЗОТЕРАПИЯ УКРАИНЫ Курсы, обучение врачей мезотерапии. Безоперационное лечение гангрены стопы.

МЕЗОТЕРАПИЯ УКРАИНЫ Курсы, обучение врачей мезотерапии. Безоперационное лечение гангрены стопы (результат).

Before and after 10 courses of mesotherapy.

·        mesotherapy of spine (treatment of osteochondrosis and neurodystrophy, stimulus therapy of lumbar spine);

·        vascular mesotherapy

·        systematic vascular mesotherapy.

At the treatment vasoactive preparations (phlebotonics, angioprotectors, preparations for improvement of microcirculation), antioxidants, narcotic and psychoactive drugs, anesthetics, anticoagulants, reparative drugs, tissue metabolics were used

Initially it was a question about the level of amputation. After the course of treatment, the patient has progressing improvement. Trophic disturbances have been almost cut off, painless period of walking has become longer, pains at rest has disappeared. The temperature of skin is symmetrical at both lower extremities and similar in different parts of extremities.

Mesotherapy and immunity. Mesoimmunocorrection

The greatest number of immunocompetent cells is in on the edge between the internal and external environment, i.e. in bowels and on skin (square of skin of an adult is about 2 square meters).

As opposed to the other injection techniques, mesotherapy allows the biggest interface, i.e. the largest number of molecules of drug, which interacts with specific receptors, in this case with immunological receptors.

Besides that diffusion in mesotherapy goes in interstices, in orthogonal way to skin, that allows to transport drugs straight to lymph nodes and necessary organs.  

So mesotherapy allows to influence very actively both on general and on local immunity, which is called general and local mesoimmunocorrection. Depending on the drugs used, both immunostimulation and immunosuppression are possible.

Mesoimmunocorrection can be used in all fields of medicine because any pathological process includes immunity mechanisms.  

An example of local mesoimmunoceoorection at inguinal lymphadenitis: creation of wide mesointerface on skin of lower extremity with mixed technique -  IED (intraepidermal) + РРР (spot after spot) IDS (superficial intradermal) .

МЕЗОТЕРАПИЯ УКРАИНЫ Курсы, обучение врачей мезотерапии. Мезоиммунокоррекция.

Mesotherapy in the treatment of pain syndromes

According to the concept given by the International Association of Pain Study (Merskey,Bogduk,1994): “Pain is an unpleasant sensation and emotional feeling, appearing in the connection with the real or potential threat of tissue injury, or presented with the concepts of such injury “.

There are 2 types of pain, or nociception:

Physiological pain is acute. It appears as a defensive reaction of an organism for some injury. It includes processes of perception of stimulus, its transformation into electric impulses, transfer to central nervous system, modulation with system of anti –nociception (anesthesia) and perception (recognition of a stimulus as pain). 

Pathological pain is chronical. Appears as a result of the formation of pathologic algetic system, including different levels of central nervous system, defining the character of all components of pathological pain (pain perception, suffering, painful behavior).   

Pathologic algetic system is formed as a result of the formation of peripheral pain sensitization and intensification of a pain impulsion flow, development of central sensitization, weakening of natural antinociceptive system, development of opiate tolerance, and creation of hyperactive neurons with weakened braking control in central nervous system.

And in case of both physiological and pathological pain, process includes the elements of central and periphery nervous system, factors of humoral regulation and immunity system, which can be influenced with the mesotherapy methods.

Mesotherapy allows cutting off sharp pain syndrome, to prevent if from transfer into pathological chronic pain, to treat chronic pain and its complications (myotonias, contractures, pain stress, visceropathys, immunodeficiency, etc.) Different methods of mesotherapy allow treating pains of traumatic, inflammatory and vascular genesis, articular and vertebrogenic pain syndromes, neuralgias, headaches, gynecological pains, visceral and stress pains, cardialgias and many others.


Mesotherapy at the treatment of stress

MESOSTRESS – usage of methods of mesotherapy in the treatment and prevention of stress and stress pathology.


Stress in general sense can be defined as «a reaction for the stimulation», that can be both physiological and pathological. At emaciation or derangement of adaptation, physiological stress situation transforms into pathological.  Pathological stress influence all organs and systems of an organism.

On somatic level – in form of functional derangements, which medicine calls neuro-vegetative dystonias that can have neuro-visceral or neuro-muscular manifestations.  Consequences of such manifestations are familiar to many patients, and, of course, to doctors. These are pains behind breast bone which are often confused with heartaches, headaches which can hardly be stopped with usual drugs, discomfort and pains in internal and genital organs, debuts or exacerbations of bronchial asthma and psoriasis, immunodeficiencies, derangements of venous and arterial blood flow and microcirculation, pathology of skin and subcutaneous fat, including cellulite and many others.


Pathology of locomotor apparatus takes the special place in somatic manifestations of stress. Pains and discomfort in spine, joints, muscles often cause a patient to consult special doctors (orthopaedists, vertebrologists), which prescribe anti-inflammatory, analgetic and myorelaxing drugs. Such treatment brings relief but not long-lasting, Relapses appears more and more often year after year, and pains become harder. Stress functional pathology of locomotor apparatus leads to the organic changes in joints, bones and muscles because long-lasting tensions and disbalances, changes in blood and lymph flow cause degenerative-dystrophy changes, and secondary immunodeficiency provokes appearance of inflectional complications and diseases.

Moreover, chronic pain is the reason of stress.

On psychic level stress appears as either psychotonic or anxious depressive syndromes. Patients with such problems go either to psychiatrists or to neurologists. They often prescribe to such patients psychotropic drugs, use and specially cancellation of which usually provoke some consequences in psychics and working capacity. Special doctors (gastroenterologists, gynecologists, cardiologists, orthopedists, immunologists and others) deal with somatic manifestations of stress.


Mesotherapy of stress has the following scale of evaluation of anxiety stress:

psychotonic anxiety (anxiété psychotonique) (A)

anxious depressive syndrome (anxiété – dépression) (D)

periphery manifestations (manifestations périphéri­ques)  (P).

According to the classification given by doctor Marie-Dominique Arigie ,  mesotherapy can be either independent, or additional method of treatment according to the level of  depression intensity.  


Clinical signs

Method of treatment

Slight depression


Contemplation of suicide = 0

Efficiency = +

Active recreation = +

Feeling of powerlessness = +

Depression management = +

Mesotherapy by itself

Middle depression

Contemplation of suicide Идея самоубийства  + or -

Efficiency = 0

Active recreation = 0

Feeling of powerlessness, emaciation

Depression management = 0

Mesotherapy, taking into account the recommendations of the psychiatrist

Heavy depression

Contemplation of suicide = +++

Preparation for suicide = +

Disability to live = +

Absence of wishes = 0

Feeling guilty = +++

Delirious ideas = +

Psychiatrist treatment, mesotherapy as an additional method


Special therapeutic procedures for the treatment of stress and stress pathology are the following:

Blocking mesotherapy;

Stimulating mesotherapy;

Meso-reflexotherapy on special reflectory zones;